Computational insights into the allosteric behavior of mini proinsulin driven by C peptide mobility
Abstract The production of recombinant insulin remains challenging, particularly in enhancing refolding efficiency and bioactivity. Mini-proinsulin analogs, which involve reducing the length of the C-peptide, offer potential improvements in insulin production. This study aims to evaluate mini-proins...
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| Format: | Article |
| Sprog: | English |
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Nature Portfolio
2025-03-01
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| Serier: | Scientific Reports |
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| Online adgang: | https://doi.org/10.1038/s41598-025-92799-8 |