Six weeks of N-acetylcysteine antioxidant in drinking water decreases pathological fiber branching in MDX mouse dystrophic fast-twitch skeletal muscle

Six weeks of N-acetylcysteine antioxidant in drinking water decreases pathological fiber branching in MDX mouse dystrophic fast-twitch skeletal muscle

Introduction: It has been proposed that an increased susceptivity to oxidative stress caused by the absence of the protein dystrophin from the inner surface of the sarcolemma is a trigger of skeletal muscle necrosis in the destructive dystrophin deficient muscular dystrophies. Here we use the mdx mo...

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Bibliographic Details
Main Authors: Asma Redwan, Leonit Kiriaev, Sindy Kueh, John W. Morley, Peter Houweling, Ben D. Perry, Stewart I. Head
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Physiology
Subjects:
mdx
skeletal muscle contraction
NAC
oxidative stress
fiber branching
muscle damage
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1109587/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1109587/full

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