LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC

LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC

Aberrant expression of lysyl oxidase-like 1 (LOXL1) reportedly leads to fibrous diseases. Recent studies have revealed its role in cancers. In this study, we observed an elevated level of LOXL1 in the tissues and sera of patients with intrahepatic cholangiocarcinoma (ICC) compared with levels in non...

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Bibliographic Details
Main Authors: Ruiyan Yuan, Yang Li, Bo Yang, Zhaohui Jin, Jiacheng Xu, Ziyu Shao, Huijie Miao, Tai Ren, Yang Yang, Guoqiang Li, Xiaoling Song, Yunping Hu, Xu’an Wang, Ying Huang, Yingbin Liu
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
angiogenesis
intrahepatic cholangiocarcinoma
lysyl oxidase-like 1
vascular endothelial cell
tumorigenesis
LOXL1
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000019

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http://www.sciencedirect.com/science/article/pii/S2162253121000019

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