Free heme exacerbates colonic injury induced by anti-cancer therapy

Free heme exacerbates colonic injury induced by anti-cancer therapy

Gastrointestinal inflammation and bleeding are commonly induced by cancer radiotherapy and chemotherapy but mechanisms are unclear. We demonstrated an increased number of infiltrating heme oxygenase-1 positive (HO-1+) macrophages (Mø, CD68+) and the levels of hemopexin (Hx) in human colonic biopsies...

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Bibliographic Details
Main Authors: Philippa Seika, Monika Janikova, Sahana Asokan, Lubica Janovicova, Eva Csizmadia, Mckenzie O’Connell, Simon C. Robson, Jonathan Glickman, Barbara Wegiel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
gastrointestinal syndrome
radiation enteritis
free heme
hemopexin
heme oxygenase-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1184105/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1184105/full

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