Codon adaptation by synonymous mutations impacts the functional properties of the estrogen receptor‐alpha protein in breast cancer cells

Codon adaptation by synonymous mutations impacts the functional properties of the estrogen receptor‐alpha protein in breast cancer cells

Oestrogen receptor‐alpha (ERα) positivity is intimately associated with the development of hormone‐dependent breast cancers. A major challenge in the treatment of these cancers is to understand and overcome the mechanisms of endocrine resistance. Recently, two distinct translation programmes using s...

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Bibliographic Details
Main Authors: Léa Clusan, Frederic Percevault, Emmanuelle Jullion, Pascale Le Goff, Christophe Tiffoche, Tamara Fernandez‐Calero, Raphaël Métivier, Monica Marin, Farzad Pakdel, Denis Michel, Gilles Flouriot
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Molecular Oncology
Subjects:
breast cancer
codon usage
co‐translational folding
endocrine resistance
oestrogen receptor alpha
Online Access:https://doi.org/10.1002/1878-0261.13399

Internet

https://doi.org/10.1002/1878-0261.13399

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