Phytochemical profile and anti-inflammatory effect of Artemisia annua L. essential oil
Plant-derived natural compounds are desired for their anti-inflammatory properties. We investigated the chemical composition and the anti-inflammatory effects of the essential oil obtained from leaves of the Chinese medicinal plant Artemisia annua L. Artemisia annua L. essential oil (AO) was obtaine...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | All Life |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/26895293.2023.2288529 |
| _version_ | 1826978983758004224 |
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| author | Congcong Zhu Ge Yan Manqi Hu Zongguang Tai Bin Fan Pei Zhao Xiao Miao Quangang Zhu |
| author_facet | Congcong Zhu Ge Yan Manqi Hu Zongguang Tai Bin Fan Pei Zhao Xiao Miao Quangang Zhu |
| author_sort | Congcong Zhu |
| collection | DOAJ |
| description | Plant-derived natural compounds are desired for their anti-inflammatory properties. We investigated the chemical composition and the anti-inflammatory effects of the essential oil obtained from leaves of the Chinese medicinal plant Artemisia annua L. Artemisia annua L. essential oil (AO) was obtained by hydrodistillation; the extraction yield was approximately 1.2%. Gas chromatography–mass spectrometry (GC–MS) revealed the presence of 13 compounds in AO; the major compounds were caryophyllene (32.16%), eucalyptol (28.62%), α-pinene (19.08%), and β-pinene (14.72%). Cell counting kit-8 (CCK8) assay revealed that AO did not show in vitro cytotoxicity toward RAW264.7 cells and suppressed the expression of nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-induced RAW264.7 cells. Pretreatment with AO significantly reduced xylene-induced inflammation in the ears of Kunming mice. AO inhibited inflammatory cell infiltration, decreased epidermis thickness in the ear, and suppressed expression of TNF-α in the serum. The in vivo anti-inflammatory activity of AO was similar to that of the positive control compound Di Song Zhang Bo Cream. Overall, AO was observed to be an effective anti-inflammatory agent. These results provide an experimental basis for commercializing AO-derived external preparations for pharmacological and cosmetic industries. |
| first_indexed | 2024-03-09T02:09:01Z |
| format | Article |
| id | doaj.art-a18bf01749654a8ba615f2d5b29c0214 |
| institution | Directory Open Access Journal |
| issn | 2689-5307 |
| language | English |
| last_indexed | 2025-02-18T05:21:52Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | All Life |
| spelling | doaj.art-a18bf01749654a8ba615f2d5b29c02142024-11-15T10:36:02ZengTaylor & Francis GroupAll Life2689-53072023-12-01160110.1080/26895293.2023.22885292288529Phytochemical profile and anti-inflammatory effect of Artemisia annua L. essential oilCongcong Zhu0Ge Yan1Manqi Hu2Zongguang Tai3Bin Fan4Pei Zhao5Xiao Miao6Quangang Zhu7Tongji UniversityShanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineTongji UniversityShanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineTongji UniversityPlant-derived natural compounds are desired for their anti-inflammatory properties. We investigated the chemical composition and the anti-inflammatory effects of the essential oil obtained from leaves of the Chinese medicinal plant Artemisia annua L. Artemisia annua L. essential oil (AO) was obtained by hydrodistillation; the extraction yield was approximately 1.2%. Gas chromatography–mass spectrometry (GC–MS) revealed the presence of 13 compounds in AO; the major compounds were caryophyllene (32.16%), eucalyptol (28.62%), α-pinene (19.08%), and β-pinene (14.72%). Cell counting kit-8 (CCK8) assay revealed that AO did not show in vitro cytotoxicity toward RAW264.7 cells and suppressed the expression of nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-induced RAW264.7 cells. Pretreatment with AO significantly reduced xylene-induced inflammation in the ears of Kunming mice. AO inhibited inflammatory cell infiltration, decreased epidermis thickness in the ear, and suppressed expression of TNF-α in the serum. The in vivo anti-inflammatory activity of AO was similar to that of the positive control compound Di Song Zhang Bo Cream. Overall, AO was observed to be an effective anti-inflammatory agent. These results provide an experimental basis for commercializing AO-derived external preparations for pharmacological and cosmetic industries.http://dx.doi.org/10.1080/26895293.2023.2288529artemisia annua ltraditional chinese medical essential oilanti-inflammationskin application |
| spellingShingle | Congcong Zhu Ge Yan Manqi Hu Zongguang Tai Bin Fan Pei Zhao Xiao Miao Quangang Zhu Phytochemical profile and anti-inflammatory effect of Artemisia annua L. essential oil All Life artemisia annua l traditional chinese medical essential oil anti-inflammation skin application |
| title | Phytochemical profile and anti-inflammatory effect of Artemisia annua L. essential oil |
| title_full | Phytochemical profile and anti-inflammatory effect of Artemisia annua L. essential oil |
| title_fullStr | Phytochemical profile and anti-inflammatory effect of Artemisia annua L. essential oil |
| title_full_unstemmed | Phytochemical profile and anti-inflammatory effect of Artemisia annua L. essential oil |
| title_short | Phytochemical profile and anti-inflammatory effect of Artemisia annua L. essential oil |
| title_sort | phytochemical profile and anti inflammatory effect of artemisia annua l essential oil |
| topic | artemisia annua l traditional chinese medical essential oil anti-inflammation skin application |
| url | http://dx.doi.org/10.1080/26895293.2023.2288529 |
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