Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress

Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related deaths globally. Despite advances in diagnosis and treatment, the incidence and mortality of HCC continue to rise. Piperlongumine (PL), an alkaloid isolated from the fruit of the long pepper,...

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Bibliographic Details
Main Authors: Qianqian Zhang, Weiqian Chen, Xiuling Lv, Qiaoyou Weng, Minjiang Chen, Ri Cui, Guang Liang, Jiansong Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
thioredoxin reductase 1
reactive oxygen species
hepatocellular carcinoma
endoplasmic reticulum stress
piperlongumine
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01180/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01180/full

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