Antiproliferative Effects of the Aptamer d(GGGT)<sub>4</sub> and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells

Antiproliferative Effects of the Aptamer d(GGGT)<sub>4</sub> and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells

In this paper, we study the T30923 antiproliferative potential and the contribution of its loop residues in six different human cancer cell lines by preparing five T30923 variants using the single residue replacement approach of loop thymidine with an abasic site mimic (S). G-rich oligonucleotides (...

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Bibliographic Details
Main Authors: Antonella Virgilio, Annalisa Pecoraro, Daniela Benigno, Annapina Russo, Giulia Russo, Veronica Esposito, Aldo Galeone
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
guanine-rich oligonucleotides
abasic site mimic
cancer
antiproliferative G-quadruplex
Online Access:https://www.mdpi.com/1422-0067/23/11/5952

Internet

https://www.mdpi.com/1422-0067/23/11/5952

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