A Spectroscopic Study on Secondary Structure and Thermal Unfolding of the Plant Toxin Gelonin Confirms Some Typical Structural Characteristics and Unravels the Sequence of Thermal Unfolding Events

A Spectroscopic Study on Secondary Structure and Thermal Unfolding of the Plant Toxin Gelonin Confirms Some Typical Structural Characteristics and Unravels the Sequence of Thermal Unfolding Events

Gelonin from the Indian plant <i>Gelonium multiflorum</i> belongs to the type I ribosome-inactivating proteins (RIPs). Like other members of RIPs, this toxin glycoprotein inhibits protein synthesis of eukaryotic cells; hence, it is largely used in the construction of immunotoxins compose...

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Bibliographic Details
Main Authors: Andrea Scirè, Fabio Tanfani, Alessio Ausili
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Toxins
Subjects:
Gelonin
Ribosome-inactivating protein
Infrared spectroscopy
Thermal unfolding
Two-dimensional correlation spectroscopy
Immunotoxins
Online Access:https://www.mdpi.com/2072-6651/11/9/483

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https://www.mdpi.com/2072-6651/11/9/483

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