PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273

PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273

Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPARγ at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK) orchestrates diabetic gene reprogr...

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Bibliographic Details
Main Authors: Keon Woo Khim, Sun Sil Choi, Hyun-Jun Jang, Yo Han Lee, Eujin Lee, Ji-Min Hyun, Hye-Jin Eom, Sora Yoon, Jeong-Won Choi, Tae-Eun Park, Dougu Nam, Jang Hyun Choi
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
obesity
insulin sensitivity
ppm1a
pparγ s273 phosphorylation
diabetic gene reprogramming
Online Access:https://www.mdpi.com/2073-4409/9/2/343

Internet

https://www.mdpi.com/2073-4409/9/2/343

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