Hyperactivation and enhanced cytotoxicity of reduced CD8+ gamma delta T cells in the intestine of patients with Crohn’s disease correlates with disease activity

Hyperactivation and enhanced cytotoxicity of reduced CD8+ gamma delta T cells in the intestine of patients with Crohn’s disease correlates with disease activity

Abstract Background and aims We aimed to investigate the immune characteristics of intestinal CD8+ gamma delta T (CD8+ γδ T) cells in Crohn’s disease (CD) and their correlation with disease activity. Methods The study cohorts included 21 CD patients and 21 healthy individuals. CD8+ γδ T cells were i...

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Bibliographic Details
Main Authors: Tao Zhu, Linlin Zhu, Caixia Sheng, Danju Wu, Qianru Gu, Zhinong Jiang, Jiaqi Xu, Guoxiang Fu, Yujie Jiang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Immunology
Subjects:
CD8+ gamma delta T cell
Crohn’s disease
Immune characteristics
Disease activity
Online Access:https://doi.org/10.1186/s12865-024-00606-2

Internet

https://doi.org/10.1186/s12865-024-00606-2

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