Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation

Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation

Summary: While a few works have shown that Mettl3 plays oncogenic roles in hepatocellular carcinoma (HCC), its function in early HCC tumorigenesis remains unclear. In Mettl3flox/flox; Alb-Cre knockout mice, Mettl3 loss leads to aberrant hepatocyte homeostasis and liver damage. Importantly, Mettl3 de...

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Bibliographic Details
Main Authors: Tao Wei, Jin Li, Jian Zhang, Qi Zhang, Xiaoyu Liu, Qi Chen, Liang Wen, Ke Ma, Wen Chen, Jianhui Zhao, Cheng Zhang, Jinyan Huang, Yali Xie, Hao Qin, Danfeng Qian, Tingbo Liang
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
liver cancer
Mettl3
tumorigenesis
m6A modification
Hnf4α
liver damage
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723007155

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http://www.sciencedirect.com/science/article/pii/S2211124723007155

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