Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation
Summary: While a few works have shown that Mettl3 plays oncogenic roles in hepatocellular carcinoma (HCC), its function in early HCC tumorigenesis remains unclear. In Mettl3flox/flox; Alb-Cre knockout mice, Mettl3 loss leads to aberrant hepatocyte homeostasis and liver damage. Importantly, Mettl3 de...
Main Authors: | Tao Wei, Jin Li, Jian Zhang, Qi Zhang, Xiaoyu Liu, Qi Chen, Liang Wen, Ke Ma, Wen Chen, Jianhui Zhao, Cheng Zhang, Jinyan Huang, Yali Xie, Hao Qin, Danfeng Qian, Tingbo Liang |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-07-01
|
Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723007155 |
Similar Items
-
The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
by: Lei Sang, et al.
Published: (2022-09-01) -
A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression
by: Chaojun Yan, et al.
Published: (2023-08-01) -
Genetically Engineered Mouse Models of Liver Tumorigenesis Reveal a Wide Histological Spectrum of Neoplastic and Non-Neoplastic Liver Lesions
by: Katja Steiger, et al.
Published: (2020-08-01) -
Downregulation of hepatic METTL3 contributes to APAP-induced liver injury in mice
by: Chunhong Liu, et al.
Published: (2023-08-01) -
METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer
by: Hao Li, et al.
Published: (2024-05-01)