Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review
Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-09-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00923/full |
| _version_ | 1828916303191080960 |
|---|---|
| author | Piril Hepsomali John A. Groeger Jun Nishihira Andrew Scholey |
| author_facet | Piril Hepsomali John A. Groeger Jun Nishihira Andrew Scholey |
| author_sort | Piril Hepsomali |
| collection | DOAJ |
| description | Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role of natural and/or biosynthetic oral GABA intake on stress and sleep are mixed. We performed a systematic review to examine whether natural and/or biosynthetic oral GABA intake has an effect on stress and sleep. We systematically searched on PubMed database for studies published up to February 2020 following PRISMA guidelines. Only placebo-controlled human trials that assessed stress, sleep, and related psychophysiological outcomes as a response to natural GABA (i.e., GABA that is present naturally in foods) or biosynthetic GABA (i.e., GABA that is produced via fermentation) intake were included. Fourteen studies met the criteria and were included in the systematic review. Although more studies are needed before any inferences can be made about the efficacy of oral GABA consumption on stress and sleep, results show that there is limited evidence for stress and very limited evidence for sleep benefits of oral GABA intake. |
| first_indexed | 2024-12-13T20:30:08Z |
| format | Article |
| id | doaj.art-a1a5c7cae5864bfbb66dcc4e31298033 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T20:30:08Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-a1a5c7cae5864bfbb66dcc4e312980332022-12-21T23:32:27ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-09-011410.3389/fnins.2020.00923559962Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic ReviewPiril Hepsomali0John A. Groeger1Jun Nishihira2Andrew Scholey3Unilever R&D, Bedford, United KingdomDepartment of Psychology, School of Social Sciences, Nottingham Trent University, Nottingham, United KingdomDepartment of Medical Management and Informatics, Hokkaido Information University, Hokkaido, JapanCentre for Human Psychopharmacology, School of Health Sciences, Swinburne University, Hawthorn, VIC, AustraliaGamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role of natural and/or biosynthetic oral GABA intake on stress and sleep are mixed. We performed a systematic review to examine whether natural and/or biosynthetic oral GABA intake has an effect on stress and sleep. We systematically searched on PubMed database for studies published up to February 2020 following PRISMA guidelines. Only placebo-controlled human trials that assessed stress, sleep, and related psychophysiological outcomes as a response to natural GABA (i.e., GABA that is present naturally in foods) or biosynthetic GABA (i.e., GABA that is produced via fermentation) intake were included. Fourteen studies met the criteria and were included in the systematic review. Although more studies are needed before any inferences can be made about the efficacy of oral GABA consumption on stress and sleep, results show that there is limited evidence for stress and very limited evidence for sleep benefits of oral GABA intake.https://www.frontiersin.org/article/10.3389/fnins.2020.00923/fullgamma amino butyric acid (GABA)stresssleepnutrientsfood supplements |
| spellingShingle | Piril Hepsomali John A. Groeger Jun Nishihira Andrew Scholey Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review Frontiers in Neuroscience gamma amino butyric acid (GABA) stress sleep nutrients food supplements |
| title | Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review |
| title_full | Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review |
| title_fullStr | Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review |
| title_full_unstemmed | Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review |
| title_short | Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review |
| title_sort | effects of oral gamma aminobutyric acid gaba administration on stress and sleep in humans a systematic review |
| topic | gamma amino butyric acid (GABA) stress sleep nutrients food supplements |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00923/full |
| work_keys_str_mv | AT pirilhepsomali effectsoforalgammaaminobutyricacidgabaadministrationonstressandsleepinhumansasystematicreview AT johnagroeger effectsoforalgammaaminobutyricacidgabaadministrationonstressandsleepinhumansasystematicreview AT junnishihira effectsoforalgammaaminobutyricacidgabaadministrationonstressandsleepinhumansasystematicreview AT andrewscholey effectsoforalgammaaminobutyricacidgabaadministrationonstressandsleepinhumansasystematicreview |