Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis

Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis

Extensive macrophage inflammatory responses and osteoclast formation are predominant during inflammatory or infective osteolysis. Mesenchymal stem cell (MSC)-derived small extracellular vesicles (MSC-sEV) have been shown to exert therapeutic effects on bone defects. However, cultured MSCs are typica...

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Bibliographic Details
Main Authors: Jun Tian, Weiyang Chen, Yuhua Xiong, Qianer Li, Siyi Kong, Mengjie Li, Chunfeng Pang, Yu Qiu, Zhezhen Xu, Qimei Gong, Xi Wei
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-04-01
Series:Bioactive Materials
Subjects:
Dental pulp stem cells
Small extracellular vesicles
Macrophage
Osteoclast
Inflammatory osteolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X2200425X

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http://www.sciencedirect.com/science/article/pii/S2452199X2200425X

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