Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases

Abstract Unnatural substituted amino acids play an important role as chiral building blocks, especially for pharmaceutical industry, where the synthesis of chiral biologically active molecules still represents an open challenge. Recently, modification of the hydrophobic binding pocket of phenylalani...

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Bibliographic Details
Main Authors: Souad Diana Tork, Mădălina Elena Moisă, Lilla Cserepes, Alina Filip, Levente Csaba Nagy, Florin Dan Irimie, László Csaba Bencze
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-14585-0