7<i>S</i>,15<i>R</i>-Dihydroxy-16<i>S</i>,17<i>S</i>-epoxy-docosapentaenoic Acid Overcomes Chemoresistance of 5-Fluorouracil by Suppressing the Infiltration of Tumor-Associated Macrophages and Inhibiting the Activation of Cancer Stem Cells in a Colorectal Cancer Xenograft Model

7<i>S</i>,15<i>R</i>-Dihydroxy-16<i>S</i>,17<i>S</i>-epoxy-docosapentaenoic Acid Overcomes Chemoresistance of 5-Fluorouracil by Suppressing the Infiltration of Tumor-Associated Macrophages and Inhibiting the Activation of Cancer Stem Cells in a Colorectal Cancer Xenograft Model

Although the tumor bulk is initially reduced by 5-fluorouracil (5-FU), chemoresistance developed due to prolonged chemotherapy in colorectal cancer (CRC). The enrichment of cancer stem cells (CSCs) and the infiltration of tumor-associated macrophages (TAMs) contribute to chemoresistance and poor out...

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Bibliographic Details
Main Authors: Yan Su, Hack Sun Choi, Jong Hyun Choi, Hee-Sik Kim, Yong-Suk Jang, Jeong-Woo Seo
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Marine Drugs
Subjects:
colorectal cancer
5-fluorouracil
7<i>S</i>,15<i>R</i>-dihydroxy-16<i>S</i>,17<i>S</i>-epoxy-docosapentaenoic acid
tumor-associated macrophages
chemoresistance
Online Access:https://www.mdpi.com/1660-3397/21/2/80

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https://www.mdpi.com/1660-3397/21/2/80

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