Radiobiological Assessment of Targeted Radionuclide Therapy with [<sup>177</sup>Lu]Lu-PSMA-I&T in 2D vs. 3D Cell Culture Models

Radiobiological Assessment of Targeted Radionuclide Therapy with [<sup>177</sup>Lu]Lu-PSMA-I&T in 2D vs. 3D Cell Culture Models

In vitro therapeutic efficacy studies are commonly conducted in cell monolayers. However, three-dimensional (3D) tumor spheroids are known to better represent in vivo tumors. This study used [<sup>177</sup>Lu]Lu-PSMA-I&T, an already clinically applied radiopharmaceutical for targeted...

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Bibliographic Details
Main Authors: Julia Raitanen, Bernadette Barta, Hermann Fuchs, Marcus Hacker, Theresa Balber, Dietmar Georg, Markus Mitterhauser
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
radiation oncology
radiobiology
multicellular tumor spheroids (3D)
targeted radionuclide therapy
[<sup>177</sup>Lu]Lu-PSMA
prostate cancer (PC-3
Online Access:https://www.mdpi.com/1422-0067/24/23/17015

Internet

https://www.mdpi.com/1422-0067/24/23/17015

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