Functional recovery and muscle atrophy in pre-clinical models of peripheral nerve transection and gap-grafting in mice: effects of 4-aminopyridine

Functional recovery and muscle atrophy in pre-clinical models of peripheral nerve transection and gap-grafting in mice: effects of 4-aminopyridine

We recently demonstrated a repurposing beneficial effect of 4-aminopyridine (4-AP), a potassium channel blocker, on functional recovery and muscle atrophy after sciatic nerve crush injury in rodents. However, this effect of 4-AP is unknown in nerve transection, gap, and grafting models. To evaluate...

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Bibliographic Details
Main Authors: Jung Il Lee, M A Hassan Talukder, Zara Karuman, Anagha A Gurjar, Prem Kumar Govindappa, Jagadeeshaprasad M Guddadarangaiah, Kristen M Manto, Grant D Wandling, John P Hegarty, David L Waning, John C Elfar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
4-aminopyridine; functional recovery; muscle atrophy; nerve gap; nerve grafting; nerve imaging; nerve transection
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=439;epage=444;aulast=

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=439;epage=444;aulast=

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