Targeted Next-Generation Sequencing Identifies Additional Mutations Other than <i>BCR∷ABL</i> in Chronic Myeloid Leukemia Patients: A Chinese Monocentric Retrospective Study

Targeted Next-Generation Sequencing Identifies Additional Mutations Other than <i>BCR∷ABL</i> in Chronic Myeloid Leukemia Patients: A Chinese Monocentric Retrospective Study

A proportion of patients with somatic variants show resistance or intolerance to TKI therapy, indicating additional mutations other than <i>BCR∷ABL1</i> may lead to TKI treatment failure or disease progression. We retrospectively evaluated 151 CML patients receiving TKI therapy and perfo...

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Bibliographic Details
Main Authors: Shiwei Hu, Dan Chen, Xiaofei Xu, Lan Zhang, Shengjie Wang, Keyi Jin, Yan Zheng, Xiaoqiong Zhu, Jie Jin, Jian Huang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
chronic myeloid leukemia (CML)
next-generation sequencing (NGS)
molecular response (MR)
tyrosine kinase inhibitor (TKI)
scoring system
Online Access:https://www.mdpi.com/2072-6694/14/23/5752

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https://www.mdpi.com/2072-6694/14/23/5752

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