T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape

T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape

Abstract Bispecific chimeric antigen receptor T-cell (CAR-T) therapies have shown promising results in clinical trials for advanced B-cell malignancies. However, it is challenging to broaden the success of bispecific CAR-T therapies to treat refractory/relapse (r/r) T-cell leukemia/lymphoma because...

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Bibliographic Details
Main Authors: Zhenyu Dai, Wei Mu, Ya Zhao, Jiali Cheng, Haolong Lin, Kedong Ouyang, Xiangyin Jia, Jianwei Liu, Qiaoe Wei, Meng Wang, Chaohong Liu, Taochao Tan, Jianfeng Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2022-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-00898-z

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https://doi.org/10.1038/s41392-022-00898-z

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