Synthesis, Density Functional Theory (DFT), Urease Inhibition and Antimicrobial Activities of 5-Aryl Thiophenes Bearing Sulphonylacetamide Moieties

Synthesis, Density Functional Theory (DFT), Urease Inhibition and Antimicrobial Activities of 5-Aryl Thiophenes Bearing Sulphonylacetamide Moieties

A variety of novel 5-aryl thiophenes 4a–g containing sulphonylacetamide (sulfacetamide) groups were synthesized in appreciable yields via Pd[0] Suzuki cross coupling reactions. The structures of these newly synthesized compounds were determined using spectral data and elemental analysis. Density fun...

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Bibliographic Details
Main Authors: Mnaza Noreen, Nasir Rasool, Yasmeen Gull, Muhammad Zubair, Tariq Mahmood, Khurshid Ayub, Faiz-ul-Hassan Nasim, Asma Yaqoob, Muhammad Zia-Ul-Haq, Vincenzo de Feo
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Molecules
Subjects:
sulfacetamide
Suzuki cross coupling reactions
urease activity
antibacterial activity
DFT
frontier molecular orbitals (FMOs) analysis
MEP
hyperpolarizability and non-linear optical (NLO) properties
Online Access:http://www.mdpi.com/1420-3049/20/11/19661

Internet

http://www.mdpi.com/1420-3049/20/11/19661

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