Estimating and Correcting for Off-Target Cellular Contamination in Brain Cell Type Specific RNA-Seq Data

Estimating and Correcting for Off-Target Cellular Contamination in Brain Cell Type Specific RNA-Seq Data

Transcriptionally profiling minor cellular populations remains an ongoing challenge in molecular genomics. Single-cell RNA sequencing has provided valuable insights into a number of hypotheses, but practical and analytical challenges have limited its widespread adoption. A similar approach, which we...

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Bibliographic Details
Main Authors: Jordan Sicherman, Dwight F. Newton, Paul Pavlidis, Etienne Sibille, Shreejoy J. Tripathy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
brain
RNA-seq
contamination
single cell
LCM-seq
TRAP-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.637143/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.637143/full

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