Numerical and experimental evaluation of ultrasound-assisted convection enhanced delivery to transfer drugs into brain tumors

Abstract Central Nervous System (CNS) malignant tumors are a leading cause of death worldwide with a high mortality rate. While numerous strategies have been proposed to treat CNS tumors, the treatment efficacy is still low mainly due to the existence of the Blood–Brain Barrier (BBB). BBB is a natur...

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Bibliographic Details
Main Authors: Ahmad Boroumand, Mehrnoush Mehrarya, Ashkan Ghanbarzadeh-Dagheyan, Mohammad Taghi Ahmadian
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23429-w