Chemical synthesis of d-ribo-phytosphingosine-1-phosphate, a potential modulator of cellular processes

d-erythro-Sphingosine-1-phosphate (2), an intermediate in sphingosine metabolism, shows a diversity of biological activities. Comparable roles might be anticipated for d-ribo-phytosphingosine-1-phosphate (1). We describe an efficient three-step chemical synthesis of 1 from d-ribo-phytosphingosine. O...

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Bibliographic Details
Main Authors: Shengrong Li, William K. Wilson, George J. Schroepfer, Jr.
Format: Article
Language:English
Published: Elsevier 1999-01-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520333460