Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis

Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis

Rescuing endothelial cells from pyroptotic cell death emerges as a potential therapeutic strategy to combat diabetic atherosclerosis. Salvianolic acid A (SAA) is a major water-soluble phenolic acid in the Salvia miltiorrhiza Bunge, which has been used in traditional Chinese medicine (TCM) and health...

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Bibliographic Details
Main Authors: Ji Zhu, Hang Chen, Yifei Le, Jianan Guo, Zhijun Liu, Xiaobing Dou, Dezhao Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
Salvianolic acid A
pyroptosis
endothelial cells
PKM2
diabetic atherosclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1009229/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1009229/full

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