Evaluation of low-pass genome sequencing in polygenic risk score calculation for Parkinson’s disease

Abstract Background Low-pass sequencing (LPS) has been extensively investigated for applicability to various genetic studies due to its advantages over genotype array data including cost-effectiveness. Predicting the risk of complex diseases such as Parkinson’s disease (PD) using polygenic risk scor...

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Bibliographic Details
Main Authors: Sungjae Kim, Jong-Yeon Shin, Nak-Jung Kwon, Chang-Uk Kim, Changhoon Kim, Chong Sik Lee, Jeong-Sun Seo
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Human Genomics
Online Access:https://doi.org/10.1186/s40246-021-00357-w