Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study

Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study

Multiple lines of evidence suggest that a deficiency of Fragile X Mental Retardation Protein (FMRP) mediates dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR<sub>5</sub>) in the pathogenesis of fragile X syndrome (FXS), the most commonly known single-gene cause of inhe...

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Bibliographic Details
Main Authors: James Robert Brašić, Jack Alexander Goodman, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Samuel D. Martin, Keith Slifer, Thomas Sedlak, Anil Kumar Mathur, John P. Seibyl, Elizabeth M. Berry-Kravis, Dean F. Wong, Dejan B. Budimirovic
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Brain Sciences
Subjects:
anterior cingulate cortex
correlation coefficient
fragile X mental retardation 1 gene (<i>FMR1</i>)
linear regression
neurodevelopmental disorders
neuroimaging
Online Access:https://www.mdpi.com/2076-3425/12/3/314

Internet

https://www.mdpi.com/2076-3425/12/3/314

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