Influence of Steric Effect on the Pseudo-Multicomponent Synthesis of <i>N</i>-Aroylmethyl-4-Arylimidazoles

Influence of Steric Effect on the Pseudo-Multicomponent Synthesis of <i>N</i>-Aroylmethyl-4-Arylimidazoles

A pseudo-three-component synthesis of <i>N</i>-aroylmethylimidazoles 3 with three new C–N bonds formed regioselectively under microwave conditions was developed. Products were obtained by reacting two equivalents of aroylmethyl bromide (ArCOCH<sub>2</sub>Br, <b>1</b&...

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Bibliographic Details
Main Authors: Nerith Rocio Elejalde-Cadena, Mayra García-Olave, David Figueroa, Pietro Vidossich, Gian Pietro Miscione, Jaime Portilla
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
amidines
<i>N</i>-aroylmethylimidazoles
DFT calculations
pseudo-MCRs
steric effect
Online Access:https://www.mdpi.com/1420-3049/27/4/1165

Internet

https://www.mdpi.com/1420-3049/27/4/1165

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