lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization

lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization

Abstract Background Hepatic fibrosis is a common consequence of chronic liver diseases without approved antifibrotic therapies. Long noncoding RNAs (lncRNAs) play an important role in various pathophysiological processes. However, the functions of certain lncRNAs involved in mediating the antifibrot...

Full description

Bibliographic Details
Main Authors: Xiaohui Han, Beichen Guo, Sicong Zhao, Yehua Li, Jing Zhu, Yifan He, Jiajun Wang, Qingbin Yao, Shuai Shao, Lina Zheng, Zhemin Shi, Tao Han, Wei Hong, Kun Zhang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cellular & Molecular Biology Letters
Subjects:
lncRNA Helf
Hepatic fibrosis
Inflammation
PTBP1
PI3K/AKT pathway
Online Access:https://doi.org/10.1186/s11658-023-00492-3

Internet

https://doi.org/10.1186/s11658-023-00492-3

Similar Items