PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation

Breakdown of the blood-brain barrier (BBB) and increased immune cell trafficking into the central nervous system (CNS) are hallmarks of the pathogenesis of multiple sclerosis (MS). Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is expressed on cells of the vascular compartment and reg...

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Bibliographic Details
Main Authors: Isabella Wimmer, Silvia Tietz, Hideaki Nishihara, Urban Deutsch, Federica Sallusto, Fabien Gosselet, Ruth Lyck, William A. Muller, Hans Lassmann, Britta Engelhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
blood-brain barrier
endothelial junctions
PECAM-1
T-cell diapedesis
vascular permeability
multiple sclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00711/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00711/full

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