Quantitative analysis of amorphous form in indomethacin binary polymorphic mixtures using infrared spectroscopy analytical techniques combined with chemometrics methods

Quantitative analysis of amorphous form in indomethacin binary polymorphic mixtures using infrared spectroscopy analytical techniques combined with chemometrics methods

Pharmaceutical corporations prefer amorphous active pharmaceutical ingredients (APIs) because of their high apparent solubility and bioavailability, which are caused by long-range disorder, large unit surface free energy, and easily wetted particle surfaces. APIs in amorphous form tend to recrystall...

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Bibliographic Details
Main Authors: Mingdi Liu, Jichao Liu, Qiuhong Wang, Ping Song, Haichao Li, Yaru Qin, Songgu Wu, Junbo Gong
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Arabian Journal of Chemistry
Subjects:
Indomethacin
Amorphous
Quantitative analysis
ATR-FTIR
NIR
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223003477

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http://www.sciencedirect.com/science/article/pii/S1878535223003477

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