Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
Mutations within Ras proteins represent major drivers in human cancer. In this study, we report the structure-based design, synthesis, as well as biochemical and cellular evaluation of nucleotide-based covalent inhibitors for KRasG13C, an important oncogenic mutant of Ras that has not been successfu...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/82184 |