Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation

Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation

A key pathological feature of Parkinson’s Disease (PD) is the progressive degeneration of dopaminergic neurons (DAns) in the substantia nigra pars compacta. Considering the major role of EN1 in the development and maintenance of these DAns and the implications from En1 mouse models, it is highly int...

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Bibliographic Details
Main Authors: Sina Hembach, Sebastian Schmidt, Tanja Orschmann, Ingo Burtscher, Heiko Lickert, Florian Giesert, Daniela Vogt Weisenhorn, Wolfgang Wurst
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Neurobiology of Disease
Subjects:
Engrailed 1
dopaminergic neuron
primary cilia
Wnt signaling
induced pluripotent stem cells
complex I
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124000731

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http://www.sciencedirect.com/science/article/pii/S0969996124000731

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