Implementation of Adenovirus-Mediated Pulmonary Expression of Human ACE2 in HLA Transgenic Mice Enables Establishment of a COVID-19 Murine Model for Assessment of Immune Responses to SARS-CoV-2 Infection

Implementation of Adenovirus-Mediated Pulmonary Expression of Human ACE2 in HLA Transgenic Mice Enables Establishment of a COVID-19 Murine Model for Assessment of Immune Responses to SARS-CoV-2 Infection

HLA transgenic mice are instrumental for evaluation of human-specific immune responses to viral infection. Mice do not develop COVID-19 upon infection with SARS-CoV-2 due to the strict tropism of the virus to the human ACE2 receptor. The aim of the current study was the implementation of an adenovir...

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Bibliographic Details
Main Authors: Theodor Chitlaru, Erez Bar-Haim, Liat Bar-On, Shahar Rotem, Hila Cohen, Uri Elia, David Gur, Moshe Aftalion, Ron Alkalay, Efi Makdasi, Yentl Evgy, Reut Falach, Ma’ayan Israeli, Adi Bercovich-Kinori, Hagit Achdout, Yfat Yahalom-Ronen, Ronit Rosenfeld, Ofer Cohen
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pathogens
Subjects:
adenovirus vector
human ACE2
SARS-CoV-2
COVID-19
HLA transgenic mice
Online Access:https://www.mdpi.com/2076-0817/10/8/940

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https://www.mdpi.com/2076-0817/10/8/940

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