Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis

Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis

A common pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the cytoplasmic mislocalization and aggregation of the DNA/RNA-binding protein TDP-43, but how loss of nuclear TDP-43 function contributes to ALS and FTD pathogenesis remains largely unknown. H...

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Bibliographic Details
Main Authors: Minggang Fang, Sara K. Deibler, Alissa L. Nana, Sarat C. Vatsavayai, Shahid Banday, You Zhou, Sandra Almeida, Alexandra Weiss, Robert H. Brown, William W. Seeley, Fen-Biao Gao, Michael R. Green
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis
frontotemporal dementia
TDP-43
DNA repair
genomic instability
homologous recombination
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1251228/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1251228/full

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