In Vitro Pharmacological Modulation of PIEZO1 Channels in Frontal Cortex Neuronal Networks

In Vitro Pharmacological Modulation of PIEZO1 Channels in Frontal Cortex Neuronal Networks

PIEZO1 is a mechanosensitive ion channel expressed in various organs, including but not limited to the brain, heart, lungs, kidneys, bone, and skin. PIEZO1 has been implicated in astrocyte, microglia, capillary, and oligodendrocyte signaling in the mammalian cortex. Using murine embryonic frontal co...

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Bibliographic Details
Main Authors: Pegah Haghighi, Mandee K. Schaub, Adam H. Shebindu, Gayathri Vijayakumar, Armaan Sood, Rafael Granja-Vazquez, Sourav S. Patnaik, Caroline N. Jones, Gregory O. Dussor, Joseph J. Pancrazio
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Brain Sciences
Subjects:
PIEZO1 channels
PIEZO1 antagonist GsMTx4
calcium imaging
cortical neurons
extracellular recording
mechanosensitive
Online Access:https://www.mdpi.com/2076-3425/14/3/223

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https://www.mdpi.com/2076-3425/14/3/223

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