The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism

The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism

Signaling through GPR109a, the putative receptor for the endogenous ligand β-OH butyrate, inhibits adipose tissue lipolysis. Niacin, an anti-atherosclerotic drug that can induce insulin resistance, activates GPR109a at nM concentrations. GPR109a is not essential for niacin to improve serum lipid pro...

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Bibliographic Details
Main Authors: Caroline E. Geisler, Kendra E. Miller, Susma Ghimire, Benjamin J. Renquist
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
GPR109a
β-OH butyrate
niacin
metabolic homeostasis
liver
Online Access:https://www.mdpi.com/1422-0067/22/8/4001

Internet

https://www.mdpi.com/1422-0067/22/8/4001

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