Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension

Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension

Postmenopausal period has been associated to different symptoms such as hot flashes, vulvovaginal atrophy, hypoactive sexual desire disorder (HSDD) and others. Clinical studies have described postmenopausal women presenting HSDD can benefit from the association of testosterone to conventional hormon...

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Bibliographic Details
Main Authors: Tiago J. Costa, Graziela S. Ceravolo, Cinthya Echem, Carolina M. Hashimoto, Beatriz P. Costa, Rosangela A. Santos-Eichler, Maria Aparecida Oliveira, Francesc Jiménez-Altayó, Eliana H. Akamine, Ana Paula Dantas, Maria Helena C. Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
Subjects:
testosterone and estrogen treatment
spontaneously hypertensive rat (SHR)
cardiovascular disease
vascular reactivity
ROS generation
cytochrome P-450 pathways
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00490/full

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http://journal.frontiersin.org/article/10.3389/fphys.2018.00490/full

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