Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity

Succinate accumulates during ischemia, and its oxidation at reperfusion drives injury. The mechanism of ischemic succinate accumulation is controversial and is proposed to involve reversal of mitochondrial complex II. Herein, using stable-isotope-resolved metabolomics, we demonstrate that complex II...

Full description

Bibliographic Details
Main Authors: Jimmy Zhang, Yves T. Wang, James H. Miller, Mary M. Day, Joshua C. Munger, Paul S. Brookes
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
succinate
heart
mitochondria
ischemia
reperfusion
complex II
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718307022

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718307022

Similar Items