Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways

Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways

NK cells are the predominant innate lymphocyte subsets specialized to kill malignant tumor cells. In patients with advanced cancer, hypoxic stress shapes NK cells toward tumor-resistant and immunosuppressive phenotypes, hence a strategy to restore NK function is critical for successful tumor immunot...

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Bibliographic Details
Main Authors: Seon Ah Lim, Yunwon Moon, Min Hwa Shin, Tae-Jin Kim, Sehyun Chae, Cassian Yee, Daehee Hwang, Hyunsung Park, Kyung-Mi Lee
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
NK cells
hypoxia
HIF-1/ERK/STAT3
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/13/8/1904

Internet

https://www.mdpi.com/2072-6694/13/8/1904

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