Novel Pyridine Bioisostere of Cabozantinib as a Potent <i>c</i>-Met Kinase Inhibitor: Synthesis and Anti-Tumor Activity against Hepatocellular Carcinoma

Novel Pyridine Bioisostere of Cabozantinib as a Potent <i>c</i>-Met Kinase Inhibitor: Synthesis and Anti-Tumor Activity against Hepatocellular Carcinoma

Two novel bioisosteres of cabozantinib, <b>3</b> and <b>4</b>, were designed and synthesized. The benzene ring in the center of the cabozantinib structure was replaced by trimethylpyridine (<b>3</b>) and pyridine (<b>4</b>), respectively. Surprisingly,...

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Bibliographic Details
Main Authors: Ujjwala Karmacharya, Diwakar Guragain, Prakash Chaudhary, Jun-Goo Jee, Jung-Ae Kim, Byeong-Seon Jeong
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal–epithelial transition factor (<i>c</i>-Met)
bioisosteric replacement
anti-proliferative activity
tumor selectivity
hepatocellular carcinoma
anti-tumor efficacy
Online Access:https://www.mdpi.com/1422-0067/22/18/9685

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https://www.mdpi.com/1422-0067/22/18/9685

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