Synthesis and Molecular Structure of Ethyl [N-tosyl-(R)-prolyloxy]-2(S)-[4-cyano-8,8-ethylenedioxy-5-oxo-5,6,7,8-tetrahydroindolizin-3-yl] Acetate, a Key Intermediate in the Total Synthesis of (20S)-Camptothecins

Synthesis and Molecular Structure of Ethyl [N-tosyl-(R)-prolyloxy]-2(S)-[4-cyano-8,8-ethylenedioxy-5-oxo-5,6,7,8-tetrahydroindolizin-3-yl] Acetate, a Key Intermediate in the Total Synthesis of (20S)-Camptothecins

The synthesis of optically active [N-tosyl-(R)-prolyloxy]-2(S)-[4-cyano-8,8-ethylenedioxy-5-oxo-5,6,7,8-tetrahydroindolizin-3-yl] acetate (4a), a key intermediate forthe total asymmetric synthesis of 20(S)-camptothecin anticancer drugs, is described. Itsstructure was characterized by 2D-NMR techniqu...

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Bibliographic Details
Main Authors: Fen-Er Chen, Yun-Yan Kuang
Format: Article
Language:English
Published: MDPI AG 2007-11-01
Series:Molecules
Subjects:
Ethyl [N-tosyl-(R)-prolyloxy]-2(S)-[4-cyano-8
8-ethylenedioxy-5-oxo-5
6
7
8-tetrahydroindolizin-3-yl] acetate
2D-NMR techniques
X-ray crystal structure
configurational analysis.
Online Access:http://www.mdpi.com/1420-3049/12/11/2507/

Internet

http://www.mdpi.com/1420-3049/12/11/2507/

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