Impaired immune surveillance accelerates accumulation of senescent cells and aging

Impaired immune surveillance accelerates accumulation of senescent cells and aging

Senescent cells accumulate with aging contributing to age-related disease and the role of the immune system in removing senescent cells is not completely understood. Here, the authors show that perforin deficient mice accumulate more senescent cells and have a shorter lifespan, and that this phenoty...

Full description

Bibliographic Details
Main Authors: Yossi Ovadya, Tomer Landsberger, Hanna Leins, Ezra Vadai, Hilah Gal, Anat Biran, Reut Yosef, Adi Sagiv, Amit Agrawal, Alon Shapira, Joseph Windheim, Michael Tsoory, Reinhold Schirmbeck, Ido Amit, Hartmut Geiger, Valery Krizhanovsky
Format: Article
Language:English
Published: Nature Portfolio 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07825-3

Internet

https://doi.org/10.1038/s41467-018-07825-3

Similar Items