Hierarchical annotation of eQTLs by H-eQTL enables identification of genes with cell type-divergent regulation
Abstract While context-type-specific regulation of genes is largely determined by cis-regulatory regions, attempts to identify cell type-specific eQTLs are complicated by the nested nature of cell types. We present hierarchical eQTL (H-eQTL), a network-based model for hierarchical annotation of bulk...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-11-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-024-03440-2 |