Hake heads proteins hydrolysates as a source of bioactive peptides with prevention against hypercholesterolemia in mice: The involvement of oxidative dysfunction in hepatic tissues
Food proteins are a source of nutraceutical and bioactive peptides that promote health and prevent diseases. The aim of this study was to evaluate the potential of Hake heads proteins hydrolysates (HHPH) in the prevention of hypercholesterolemia, oxidative stress and obesity in mice fed a high chole...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Food Chemistry Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772753X23000862 |
| _version_ | 1797796068745805824 |
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| author | Wafa Karoud Noura Brahmi Houda Hamed Mohamed Salah Allagui Ali Bougatef Assaâd Sila |
| author_facet | Wafa Karoud Noura Brahmi Houda Hamed Mohamed Salah Allagui Ali Bougatef Assaâd Sila |
| author_sort | Wafa Karoud |
| collection | DOAJ |
| description | Food proteins are a source of nutraceutical and bioactive peptides that promote health and prevent diseases. The aim of this study was to evaluate the potential of Hake heads proteins hydrolysates (HHPH) in the prevention of hypercholesterolemia, oxidative stress and obesity in mice fed a high cholesterol diet. After six week of treatment serum lipid profiles (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol), the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the thiobarbituric acid-reactive substances (TBARS) level, the advanced oxidation protein product (AOPP) and the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) were tested. The high cholesterol diet led to dyslipidemia, oxidative stress and liver structure damage, compared with the control group. It is interesting to note that the addition of HHPH to the HCD attenuated these anomalies in a dose-dependent manner. The overall findings revealed that the hypocholesterolemic effect of HHPH could be due to their capacity to diminish serum total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels as well as to their antioxidant activities by improving the liver architecture. |
| first_indexed | 2024-03-13T03:27:34Z |
| format | Article |
| id | doaj.art-a1f1bfa5e60946628ec4a42500031ad4 |
| institution | Directory Open Access Journal |
| issn | 2772-753X |
| language | English |
| last_indexed | 2024-03-13T03:27:34Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry Advances |
| spelling | doaj.art-a1f1bfa5e60946628ec4a42500031ad42023-06-25T04:44:50ZengElsevierFood Chemistry Advances2772-753X2023-10-012100266Hake heads proteins hydrolysates as a source of bioactive peptides with prevention against hypercholesterolemia in mice: The involvement of oxidative dysfunction in hepatic tissuesWafa Karoud0Noura Brahmi1Houda Hamed2Mohamed Salah Allagui3Ali Bougatef4Assaâd Sila5Laboratory for the Improvement of Plants and Valorization of Agroresources, National School of Engineering of Sfax (ENIS), University of Sfax, TunisiaAnimal Ecophysiology Laboratory, Department of Life Sciences, Faculty of sciences, University of Sfax Tunisia, Road of Soukra Km 3.5, BP 1171, PC 3000 Sfax, TunisiaAnimal Ecophysiology Laboratory, Department of Life Sciences, Faculty of sciences, University of Sfax Tunisia, Road of Soukra Km 3.5, BP 1171, PC 3000 Sfax, TunisiaAnimal Ecophysiology Laboratory, Department of Life Sciences, Faculty of sciences, University of Sfax Tunisia, Road of Soukra Km 3.5, BP 1171, PC 3000 Sfax, Tunisia; Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems, University of Gafsa, Gafsa, 2112, TunisiaLaboratory for the Improvement of Plants and Valorization of Agroresources, National School of Engineering of Sfax (ENIS), University of Sfax, Tunisia; Corresponding author.Laboratory for the Improvement of Plants and Valorization of Agroresources, National School of Engineering of Sfax (ENIS), University of Sfax, Tunisia; Department of Life Sciences, Faculty of Sciences of Gafsa, University of Gafsa, 2100 Gafsa, TunisiaFood proteins are a source of nutraceutical and bioactive peptides that promote health and prevent diseases. The aim of this study was to evaluate the potential of Hake heads proteins hydrolysates (HHPH) in the prevention of hypercholesterolemia, oxidative stress and obesity in mice fed a high cholesterol diet. After six week of treatment serum lipid profiles (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol), the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the thiobarbituric acid-reactive substances (TBARS) level, the advanced oxidation protein product (AOPP) and the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) were tested. The high cholesterol diet led to dyslipidemia, oxidative stress and liver structure damage, compared with the control group. It is interesting to note that the addition of HHPH to the HCD attenuated these anomalies in a dose-dependent manner. The overall findings revealed that the hypocholesterolemic effect of HHPH could be due to their capacity to diminish serum total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels as well as to their antioxidant activities by improving the liver architecture.http://www.sciencedirect.com/science/article/pii/S2772753X23000862Cholesterol-enriched dietHepatoprotectiveHypocholesterolemicMerluccius merlucciusOxidative stressProtein hydrolysates |
| spellingShingle | Wafa Karoud Noura Brahmi Houda Hamed Mohamed Salah Allagui Ali Bougatef Assaâd Sila Hake heads proteins hydrolysates as a source of bioactive peptides with prevention against hypercholesterolemia in mice: The involvement of oxidative dysfunction in hepatic tissues Food Chemistry Advances Cholesterol-enriched diet Hepatoprotective Hypocholesterolemic Merluccius merluccius Oxidative stress Protein hydrolysates |
| title | Hake heads proteins hydrolysates as a source of bioactive peptides with prevention against hypercholesterolemia in mice: The involvement of oxidative dysfunction in hepatic tissues |
| title_full | Hake heads proteins hydrolysates as a source of bioactive peptides with prevention against hypercholesterolemia in mice: The involvement of oxidative dysfunction in hepatic tissues |
| title_fullStr | Hake heads proteins hydrolysates as a source of bioactive peptides with prevention against hypercholesterolemia in mice: The involvement of oxidative dysfunction in hepatic tissues |
| title_full_unstemmed | Hake heads proteins hydrolysates as a source of bioactive peptides with prevention against hypercholesterolemia in mice: The involvement of oxidative dysfunction in hepatic tissues |
| title_short | Hake heads proteins hydrolysates as a source of bioactive peptides with prevention against hypercholesterolemia in mice: The involvement of oxidative dysfunction in hepatic tissues |
| title_sort | hake heads proteins hydrolysates as a source of bioactive peptides with prevention against hypercholesterolemia in mice the involvement of oxidative dysfunction in hepatic tissues |
| topic | Cholesterol-enriched diet Hepatoprotective Hypocholesterolemic Merluccius merluccius Oxidative stress Protein hydrolysates |
| url | http://www.sciencedirect.com/science/article/pii/S2772753X23000862 |
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