Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder
Abstract Background Although prior observational studies indicate an association between cardiovascular diseases (CVDs) and frozen shoulder (FS), the potential causal relationship between them remains uncertain. This study aims to explore the genetic causal relationship between CVDs and FS using Men...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-024-04600-7 |
| _version_ | 1797273827616489472 |
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| author | WeiSong Lu Bin Pu Sen Wang MengZe Li Yue An Jie Lian YongQuan Wang |
| author_facet | WeiSong Lu Bin Pu Sen Wang MengZe Li Yue An Jie Lian YongQuan Wang |
| author_sort | WeiSong Lu |
| collection | DOAJ |
| description | Abstract Background Although prior observational studies indicate an association between cardiovascular diseases (CVDs) and frozen shoulder (FS), the potential causal relationship between them remains uncertain. This study aims to explore the genetic causal relationship between CVDs and FS using Mendelian randomization (MR). Methods Genetic variations closely associated with FS were obtained from the FinnGen Consortium. Summary data for CVD, including atrial fibrillation (AF), coronary artery disease (CAD), heart failure (HF), myocardial infarction (MI), stroke, and ischemic stroke (IS), were sourced from several large-scale genome-wide association studies (GWAS). MR analysis was performed using inverse variance weighting (IVW), MR Egger, and weighted median methods. IVW, as the primary MR analysis method, complemented by other sensitivity analyses, was utilized to validate the robustness of the results. Further reverse MR analysis was conducted to explore the presence of reverse causal relationships. Results In the forward MR analysis, genetically determined risk of stroke and IS was positively associated with FS (OR [95% CI] = 1.58 (1.23–2.03), P < 0.01; OR [95% CI] = 1.46 (1.16–1.85), P < 0.01, respectively). There was no strong evidence of an effect of genetically predicted other CVDs on FS risk. Sensitivity analyses confirmed the robustness of the results. In the reverse MR analysis, no causal relationships were observed between FS and various CVDs. Conclusion The study suggests that stroke increases the risk of developing FS. However, further basic and clinical research is needed to substantiate our findings. |
| first_indexed | 2024-03-07T14:49:48Z |
| format | Article |
| id | doaj.art-a1f242f49c6a4ebf903b7f227882fb9a |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-07T14:49:48Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-a1f242f49c6a4ebf903b7f227882fb9a2024-03-05T19:46:05ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2024-02-0119111010.1186/s13018-024-04600-7Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulderWeiSong Lu0Bin Pu1Sen Wang2MengZe Li3Yue An4Jie Lian5YongQuan Wang6Luzhou Hospital of Traditional Chinese MedicineGuangzhou University of Chinese MedicineLuzhou Hospital of Traditional Chinese MedicineLuzhou Hospital of Traditional Chinese MedicineLuzhou Hospital of Traditional Chinese MedicineLuzhou Hospital of Traditional Chinese MedicineLuzhou Hospital of Traditional Chinese MedicineAbstract Background Although prior observational studies indicate an association between cardiovascular diseases (CVDs) and frozen shoulder (FS), the potential causal relationship between them remains uncertain. This study aims to explore the genetic causal relationship between CVDs and FS using Mendelian randomization (MR). Methods Genetic variations closely associated with FS were obtained from the FinnGen Consortium. Summary data for CVD, including atrial fibrillation (AF), coronary artery disease (CAD), heart failure (HF), myocardial infarction (MI), stroke, and ischemic stroke (IS), were sourced from several large-scale genome-wide association studies (GWAS). MR analysis was performed using inverse variance weighting (IVW), MR Egger, and weighted median methods. IVW, as the primary MR analysis method, complemented by other sensitivity analyses, was utilized to validate the robustness of the results. Further reverse MR analysis was conducted to explore the presence of reverse causal relationships. Results In the forward MR analysis, genetically determined risk of stroke and IS was positively associated with FS (OR [95% CI] = 1.58 (1.23–2.03), P < 0.01; OR [95% CI] = 1.46 (1.16–1.85), P < 0.01, respectively). There was no strong evidence of an effect of genetically predicted other CVDs on FS risk. Sensitivity analyses confirmed the robustness of the results. In the reverse MR analysis, no causal relationships were observed between FS and various CVDs. Conclusion The study suggests that stroke increases the risk of developing FS. However, further basic and clinical research is needed to substantiate our findings.https://doi.org/10.1186/s13018-024-04600-7Frozen shoulderCardiovascular diseasesMendelian randomizationGenome-wide association studies |
| spellingShingle | WeiSong Lu Bin Pu Sen Wang MengZe Li Yue An Jie Lian YongQuan Wang Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder Journal of Orthopaedic Surgery and Research Frozen shoulder Cardiovascular diseases Mendelian randomization Genome-wide association studies |
| title | Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder |
| title_full | Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder |
| title_fullStr | Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder |
| title_full_unstemmed | Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder |
| title_short | Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder |
| title_sort | bidirectional two sample mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder |
| topic | Frozen shoulder Cardiovascular diseases Mendelian randomization Genome-wide association studies |
| url | https://doi.org/10.1186/s13018-024-04600-7 |
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