Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy

Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy

We show here that soluble CD137 (sCD137), the alternately spliced gene product of Tnfsfr9, effectively treats acute type 1 diabetes (T1D) in nonobese diabetic (NOD) mice. sCD137 significantly delayed development of end-stage disease, preserved insulin+ islet beta cells, and prevented progression to...

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Bibliographic Details
Main Authors: Arata Itoh, Lorenzo Ortiz, Kritika Kachapati, Yuehong Wu, David Adams, Kyle Bednar, Shibabrata Mukherjee, Claire Chougnet, Robert S. Mittler, Yi-Guang Chen, Laurence Dolan, William M. Ridgway
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
autoimmunity
T cells
T cell anergy
soluble CD137
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02566/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02566/full

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