Comparative Studies of Palmatine with Metformin and Glimepiride on the Modulation of Insulin Dependent Signaling Pathway In Vitro, In Vivo & Ex Vivo

Comparative Studies of Palmatine with Metformin and Glimepiride on the Modulation of Insulin Dependent Signaling Pathway In Vitro, In Vivo & Ex Vivo

(1) Insulin resistance, a symptom of type 2 diabetes mellitus (T2DM), is caused by the inactivation of the insulin signaling pathway, which includes IRS-PI3K-IRS-1-PKC-AKT2 and GLUT4. Metformin (biguanide) and glimepiride (sulfonylurea) are both drugs that are derivatives of urea, and they are widel...

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Bibliographic Details
Main Authors: Okechukwu Patrick Nwabueze, Mridula Sharma, Abbirami Balachandran, Anand Gaurav, Anis Najwa Abdul Rani, Jeleń Małgorzata, Morak-Młodawska Beata, Charlie A. Lavilla, Merell P. Billacura
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceuticals
Subjects:
T2DM
palmatine
metformin
glimepiride
IRS1
PI3K
Online Access:https://www.mdpi.com/1424-8247/15/11/1317

Internet

https://www.mdpi.com/1424-8247/15/11/1317

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