Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility

Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility

ABSTRACT Bacteria can adapt to stressful conditions through mutations affecting the RNA polymerase core subunits that lead to beneficial changes in transcription. In response to selection with rifampicin (RIF), mutations arise in the RIF resistance-determining region (RRDR) of rpoB that reduce antib...

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Bibliographic Details
Main Authors: Yesha Patel, Vijay Soni, Kyu Y. Rhee, John D. Helmann
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
Bacillus subtilis
Mycobacterium tuberculosis
RNA polymerases
antibiotic resistance
antibiotic synergy
β-lactams
Online Access:https://journals.asm.org/doi/10.1128/mbio.03168-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03168-22

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